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Although we had a large sampling size, one inadequacy was our failure to have a placebo-controlled crossover design of treatment

Cohen's d = 1.06
Long, Zeng, Shi, Tian, and Chen at West China Hospital of Sichuan University published a systematic review and meta-analysis in Free Radical Research in 2014, pooling data from 35 prospective studies involving 571,511 participants and 72,196 deaths