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This depletion is tightly linked to the breakdown of immune homeostasis, intestinal barrier dysfunction, and uncontrolled systemic inflammation, underscoring Clostridium s potential as a core target for microbiota-based immunotherapy

Consider the filter porosity in filter column as , mass concentration of DO in inflow and outflow are (DO i ) and (DO e ) respectively, taking d as the micro-unit taken from depth of in bio-filter bed ( is section area of filer column, m 2 ), and the variation in DO caused by the effect of microbe inside the micro-unit can be described as (1-)d, according to the law of conservation of mass: ISOUR can be described as In this equation: Q stands for the quantity of water through the filter column, m 3 /h

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Thry, Y., Bonjean, P., Calen, S., & Roques, J