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Moreover, the long-term effects and safety of therapeutic interventions targeting the gut-brain-metabolic axis, such as probiotics, prebiotics, and FMT, are not well-established

Further investigation into the modulation of NQO1 function without causing adverse effects and evaluation of additional molecules that interact with NQO1 in the context of PD, particularly on post-mortem specimens or induced pluripotent stem cell-derived neuronal cultures from PD patients, could potentially reveal new therapeutic opportunities

Common side effects include nausea, vomiting, constipation, heartburn, and in rare cases cholecytitis and pancreatitis have been reported

ROS in auto-oxidation initiates the oxidation of polyunsaturated fatty acids (PUFAs), especially arachidonic acid peroxide and adrenalin, leading to the accumulation of peroxides