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Thus, despite substantial controversy surrounding the view that APAP causes neurodevelopmental injury in susceptible individuals, this debate and its surrounding controversy are primarily focused on the relatively limited evidence pointing specifically toward the prenatal period

Although conjugating DFO to polymers has prolonged drug circulation, safe and effective chelating materials for chelation therapy should also possess features capable of regulating iron chelation levels to avoid removing too much iron too fast from cells, oxidation-induced degradable properties suitable for eliminating iron-bound chelates from the body and an overall lower drug cytotoxicity profile

10.1016/j.archger.2022.104895 100 SaxamiG.KerezoudiE

However, BA effects are context-dependent