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Acknowledgements We apologize to all the scientists whose work could not be discussed in the pages of this review

NOX, NADPH oxidase

The TGF-1/Smad3 pathway is a key driver of this process, inducing the expression of fibrotic markers such as -SMA and collagen I, promoting interstitial remodeling

Schmitt, B., Vicenzi, M., Garrel, C., & Denis, F
