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Thus, the feedforward loop connecting P62 and Nrf2 is destroyed, the antioxidant capacity of testis is reduced, and the oxidative stress of testis is further aggravated, forming a vicious circulation (Tian et al

& Fraser, P

Molecular nutrition & food research

However, even when sufficient tumor-specific T-cell clones are present, their functional state and differentiation fate within the immunosuppressive TME are equally critical, as an unsustainable immune response ultimately leads to treatment failure
