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BMJ 316 : 894898 Horton TM, Blaney SM, Langevin A-M, Kuhn J, Kamen B, Berg SL, Bernstein M, Weitman S (2005) Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study

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Who Should Avoid It Pregnancy or breastfeeding Pre-existing metabolic conditions (consult healthcare provider) Stop Right Away If You Notice Severe gastrointestinal upset or persistent nausea Unusual fatigue or weakness (opposite of expected effect) Persistent headaches or dizziness Sleep disturbances or insomnia Allergic reactions (rash, swelling, difficulty breathing) Significant mood changes or anxiety Milder Signs to Watch For How Long Should a 5-Amino-1MQ Cycle Last

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