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10.1159/000490019 22 ChengJ.-H.HungC.-F.YangS.-C.WangJ.-P.WonS.-J.LinC.-N

Delivery of bioactive molecules to mitochondria in vivo [J]

This S N 2-type nucleophilic substitution mechanism is a one-step reaction, whereby, in the case of NAC, the thiolate in NAC binds to the central sulfur of the disulfide, thus breaking the disulfide bond and the leaving thiol released via a trisulfide-like transition state structure [37,194]
10.1074/jbc.m204672200 128 MasahitoT.SeiyaI.FumihikoH.TakanoriT
