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Conclusion: Future work will involve expanding sample size and conducting targeted proteomics on a larger cohort of EV samples to validate diagnostic potential
doi: 10.1186/2045-9912-2-11
The activation phase is initiated by danger signals (e.g., ROS (O 2 - , H 2 O 2 ), lysosomal rupture, or K + efflux), leading to NLRP3 oligomerization, recruitment of the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC), and activation of pro-caspase-1 [41]
Poor Diet: Processed foods and high sugar intake can lead to increased oxidative stress, using up your available stores
