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Clinical characterization and therapeutic outcomes of patients (pts) with colorectal cancer (CRC) harboring somatic BRCA1/2 mutations

Glutaminolysis: beyond carbon source Glutaminolysis is a critical pathway in NSCLC, where cancer cells exhibit glutamine addiction. Glutamine serves multiple essential functions: it provides carbon and nitrogen for anabolic processes including nucleotide and amino acid biosynthesis, fuels the TCA cycle through anaplerosis, and maintains redox balance through glutathione production

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However, this is not the entire explanation, as estradiol also stimulates GPX, resulting in higher GPX flux that removes more mass from GSH