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[1] Unlike the folic acid derivative leucovorin, folic acid is not clinically useful in offsetting the action of folate reductase inhibitors because it requires the enzyme dihydrofolate reductase for activation

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Consequently, infiltration is often sufficient for extraction of mandibular anterior teeth in many patients

Impact upon activities of daily living and QoL were some secondary measures, which were also reduced in the subcutaneous B12 group but not the two control groups
