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Standard protocols use 6001,200mg in a saline push or slow drip over 1015 minutes

Further supporting the importance of arnT , a deletion mutant study in Salmonella Typhimurium (JOL2943) demonstrated that loss of arnT leads to significantly reduced resistance to PMB, impaired intracellular survival, diminished biofilm and swarming capacity, and lower induction of cytokines such as IL-1 in host cells

The possible underlying mechanism is associated with enhanced hepatic lipid oxidation via an Adenosine Monophosphate- Activated Protein Kinase- Acetyl-CoA carboxylase (AMPKAcetyl-CoA carboxylase) pathway, which leads to a reduction in liver fatty acid synthase activity, an increase in glycogen storage, and a decrease in tumor necrosis factor expression [157]