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The most-studied effect
[11] [4] Preclinical studies have suggested that combining amylin receptor agonism with GLP-1based therapies produces greater reductions in food intake and body weight than either approach in isolation, and early clinical data from the CagriSema programme (cagrilintide combined with semaglutide) has provided some supporting evidence in humans
Cagrilintide vs semaglutide Semaglutide is the dominant GLP-1 receptor agonist, with extensive clinical data showing approximately 15-17% body weight reduction at the 2.4 mg weekly dose
