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They apply whether you are using a pre-filled pen or drawing from a reconstituted vial with a syringe

There are a number of benefits to it: Cost
N-Acetyl-L-Cysteine (NAC) : A source of cysteine that is widely used in antioxidant supplement products

If your protocol calls for very small doses (under 50 mcg), consider 2 mL instead to make measurements more practical
