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Besides the acute phase gastrointestinal effects which may lead to up to 10% of people discontinuing the drugs, there are other potential GI side effects of obstruction, excessive loss of muscle mass, and potentially association with some eye disease adverse events
These properties are relevant given the established role of HGH in cartilage growth and repair through the local stimulation of IGF-1

Zapf J, Hauri C, Waldvogel M, Froesch ER

Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
