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Description
TMAO was found to exacerbate myocardial hypertrophy and cardiac fibrosis in rodent models with transverse aortic constriction and also in mouse models of doxorubicin (DOX)-induced cardiac fibrosis (Organ et al., 2016

Each mouse was measured 5 times to gather a representative number of measurements

Anesthesiology 96 , 10531061 (2002)

[16] FishTMAO Paradox: Why Seafood Can Raise TMAO Yet Support Heart Health Seafood may acutely elevate circulating TMAO because it contains TMAO itself, but long-term fish consumption aligns with lower CVD risk in prospective evidence and is regularly recommended in heart-healthy dietary guidance
