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Supporting a role for these microglia changes in disease pathology is the fact that a remarkable overlap exists between the sites of cellular pathology and the brain regions with altered structure and function in neuroimaging studies of bipolar illness (164)

The combination of senolytics and senomorphics could rejuvenate both bone and muscle tissue by eliminating senescent cells and modulating the inflammatory environment that promotes bone resorption and muscle wasting.215 Such therapies could reduce the risk of fractures, improve muscle strength, and enhance mobility in the elderly.216 Cancer: Cellular senescence is a double-edged sword in cancer

In summary, neuroprotective capacity is a major differentiator: natural compounds engage pathways (antioxidant responses, antiapoptosis, protein homeostasis, etc.) that maintain neuron health, whereas levodopa largely bypasses these diseasemodifying mechanisms (Figure 5)