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Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

But only a maximum of 5mcg of B12 enters the bile every day (according to "Advanced Haematology" 7th edition textbook, page 60), so it seems that only an additional 5mcg would be lost daily if none was recovered

The steps of the procedure are as follows: The jejunum (middle portion of the small intestine) is transected distal to the ligament of Treitz

The pink color from B12 does not affect the effectiveness of tirzepatide for weight loss or blood sugar management