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Skin fibroblasts expressing progerin exhibit: Flattened, irregular nuclei Increased oxidative stress Reduced collagen and elastin gene expression Slower cellular turnover UV radiation further accelerates progerin production in sun-exposed areas, which is why photoaged skin often appears older than biologically aged skin

I was nearly 20 minutes early to my scheduled appointment

TL;DR (Summary) ~15% reduction in visceral fat Minimal change in subcutaneous fat No major safety signal in randomized controlled trials This is one of the few interventions shown to selectively reduce visceral fat in humans

The PAOX gene is located on chromosome 10q26.3 and is composed of 8 exons that generate three alternatively spliced mRNAs, each of which encode a distinct protein isoform