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FIGURE 2 FIGURE 3 Second, we examined the associations between PROMIS-Fatigue T -scores and metabolites that significantly distinguished the +ADT group from the ADT group

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Integrin receptors within the stromal extracellular matrix (ECM) are critical in this regard,133,147 as they constitute the first point of contact for disseminating cancer cells, permitting adhesion to the pre-metastatic niche.148 Cancer-associated fibroblasts (CAFs) define ECM composition and promote tumour progression by regulating integrins and signalling pathways such as TGF-.149 Nevertheless, the precise mechanisms by which the ECM governs cancer-cell dormancy remain to be elucidated

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