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Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium

For example, TGF- family ligands participate in cardiac remodeling after infarction via regulation of inflammation and repair [3] and excessive TGF- signaling can also lead to cardiac fibrosis [4]

Importantly, combining mTORC1 inhibitors with imidazole ketone erastin (IKE), a bioavailable ferroptosis inducer, exhibited synergistic tumor-suppressing effects in patient-derived xenografts of lung cancer

The antioxidant system in the brain consists of several enzymes and molecules, including superoxide dismutase, catalase, GPx, and GSH