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Tissue-plasminogen activator (TPA) converts plasminogen to plasmin, which then catalyzes fibrinolysis
In contrast, nanoparticles with localized or patchy positive charges on a well-hydrated surface for example, chitosan-coated PEGylated nanoparticles can maintain sufficient adhesion and permeability while reducing irritation compared with uniformly high-zeta-potential systems

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After the addition of a pro-chromogenic solution and a 5 min incubation at 37 C, a second absorbance was recorded
