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Mounjaro works by mimicking 2 hormones involved in appetite regulation, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)

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BCAAs are transported into the mitochondria through SLC25A44, where mitochondrial BCAT (BCATm) catalyzes reversible transamination of BCAAs to produce the branched-chain ketoacids (BCKAs) -ketoisovalerate (KIV), -keto--methylvalerate (KMV), and -ketoisocaproate (KIC)

For weight management, some patients may use the medication until achieving their goal weight and then attempt to maintain weight loss through lifestyle modifications alone, while others may require continued treatment to prevent weight regain