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doi: 10.3389/fmed.2022.997190 42 DidonaD.HertlM
Simplified lipid nanoparticles for tissue- and cell-targeted mRNA delivery facilitate precision tumor therapy in a lung metastasis mouse model
Pharmacological inhibition of this pathway by agents such as erastin depletes GSH reserves, directly inactivating GPX4 through loss of reducing power and culminating in uncontrolled membrane lipid peroxidation ( 3.3.2 Nrf2/ARE axis Transcription factor Nrf2 is a core regulator of cellular oxidative stress responses
