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It is characterized by reduced effector function, the expression of inhibitory receptors, and specific transcriptional pathways that differ from those in effector or memory T cells (202)
doi: 10.1016/j.ifset.2017.11.007
This dissociation underscores the principle that biomarker improvement does not equate to immediate, measurable clinical benefit, suggesting a potential delay between biological effect and functional stabilization (47)
However, Dihexa-treated APP/PS1 mice had significantly downregulated expression of GFAP and Iba-1
