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Mechanistic endpoints were recorded when available, including markers of inflammation, angiogenic activity, collagen organization, and bone remodeling

RC received institutional grants from Amgen, Amryt Pharma, Novartis, and Sanofi and received honoraria for consulting and lectures from Amgen, Amryt Pharma, Astra Zeneca, Bayer, Boehringer Ingelheim, ExCEEd Orphan, Sanofi, Zentiva, AOP Orphan, Bayer, Roche, and Servier