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doi: 10.3168/jds.2019-17929 11

The Large Folate Cycle The large folate cycle consists of three substances: Tetrahydrofolate (THF) 5, 10-Methylenetetrahydrafolate Methylfolate (5-MTHF) The folate cycle is responsible for converting tetrahydrofolate (THF) into initially 5, 10-methylenetetrahydrafolate and finally methylfolate (5-MTHF)

Nirogacestat was initially developed to treat Alzheimers disease, but the drug proved to be ineffective against that disease

Cisplatin induces stemness in ovarian cancer
