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Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
A year later, the synergic effect of metformin and rapamycin was evaluated in a pancreatic cancer cell line (SW1990) where a reduced cell proliferation was observed, moreover, cell viability was also reduced when cells were treated with both rapamycin and metformin, importantly, an evaluation of phosphorylated mTOR showed that only a combination of the two drugs was capable to suppress the mTOR pathway
Neuroscience 102, 121128
DeMuynck C, De Vroe C, Remon JP et al
