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In addition to natural aging, environmental causes include: Chronic exposure to chemical toxins Cadmium exposure Alcohol use Smoking Pollution Poor diet (Standard American Diet (SAD)) Stress Certain medications (Tylenol) UV radiation exposure Certain illnesses are known to decrease glutathione levels

J Appl Physiol 63:152157 Huang J, Philbert MA (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells

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