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An addictive substance induces a pleasant state, triggers tolerance and causes dependence

A Volume of subcutaneous tumour size between group control and groups shASS1/shPYCR1

In agreement with observed resistance in KO mice, levels of phosphorylated AMPK subunit (at Thr172 residue) were higher in the livers of KO mice than in WT mice in all diet groups (Fig

Chalmers, J
