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In addition, the Ser558 site in the Neh1 domain of Nrf2 has been identified as a direct phosphorylation site of AMPK ( 2+ -CaMKK-AMPK pathway
& Gadek, J
209 The absence of orthotopic or genetically engineered mouse models (GEMMs) limits the ability to assess context-dependent ferroptotic responses and may obscure tissue-specific toxicities or therapeutic windows
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