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30 A 2021 meta-analysis on the effects of B12 on cognitive function found no benefit with either B12 alone (based on four RCTs) or B12 combined with other B vitamins (based on 13 studies)

doi: 10.1289/ehp.1103582 131 RudelRAGrayJMEngelCLRawsthorneTWDodsonREAckermanJMet al

doi: 10.1007/s12178-025-09990-7
Adequate hydration, fiber intake, and in some cases magnesium supplementation can address this
