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Indeed, treatment with relatively high doses of antioxidants can even be linked to potential adverse effects due to interference with reactive oxygen and nitrogen species involved in normal cellular signaling (Frein et al

Indeed, the above postulations are in agreement with murine and cellular studies wherein the supplementation of selenite or SeM has shown the saturated level of GPx activity and radioprotection [42,43,44,45,46,47,48,49,50]

Together, these data identify SLC25A40 as a key regulator that sustains ETC integrity to promote cytokine production, revealing a previously unrecognized role for the SLC25A40-mtGSH axis in coupling mitochondrial redox control to macrophage activation

& Butterfield, L