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Description
Ex vivo , adipose tissue extracellular fraction (AT-Ex) induces melanocyte intracellular antioxidant enzymes via acting on nuclear factor (erythroid-derived 2) -like (Nrf-2) to counteract oxidative stress, promotes cell proliferation, and inhibits GSK3 to activate Wnt/-catenin signaling 122

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Folate and B12 deficiency are also known to increase uracil incorporation into DNA, leading to DNA damage, which can result in the development of CRC [93,94] (Figure 2A)