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These cellular actions align with the observed behavioral and cognitive benefits in preclinical models, emphasizing lithiums role in maintaining neuroimmune balance and mitochondrial integrity

These mice display motor neuron degeneration and resultant muscle atrophy and weakness similar to human ALS phenotypes
While the incidence and mortality of lung cancer have shown a downward trend in countries such as the United Kingdom and the United States, driven by the popularization of early detection technologies and advances in targeted therapy, immunotherapy, and other advanced treatment modalities (Siegel et al., 2025

Consequently, ACSL4 is considered a critical 'gatekeeper' enzyme for ferroptosis, as its expression level and activity cellular sensitivity to ferroptosis
