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Description
When hepatocytes are exposed to toxic drugs like sulfamethoxazole or flucloxacillin, they can trigger dendritic cells to release proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 alpha and beta (IL-1, IL-1)

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363 Gpx4-deficient activated Tregs are susceptible to ferroptosis and exhibit enhanced production of the proinflammatory cytokine IL-1, leading to a promotion of T helper cell 17 (Th17) responses

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