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In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)

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However, PEG 8000 increased the K D with greater effect at higher concentration, and Ficoll PM 70 showed no concentration-dependent effect on K D or T t (Supplementary Fig