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Closed-head impact model of engineered rotational acceleration (CHIMERA) model has offered versatility in terms of controlled severity of injury, ranging from 0.7 joules simulating a mild TBI model to 2.5 joules simulating a more severe injury types, based on robust acute neurological deficits, enhanced plasma total tau and neurofilament-light levels, increased pro-inflammatory markers, microgliosis and BBB compromise (Vonder Haar et al., 2019)

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Future directions: open scientific and clinical questions How can long-term safety, biodistribution, and immunocompatibility of multifunctional nanomaterials be reliably assessed in humans