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Description
The inhibition of UPS results in the perturbation of intracellular protein homeostasisfundamental for cell function and viabilityby the accumulation of poly-ubiquitinated proteins, which subsequently induces cellular stress and apoptosis

This marked the beginning of modern keratopigmentation

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Analysis of stool samples can reveal the presence of inflammatory markers, such as calprotectin and lactoferrin, which indicate heightened immune activity and intestinal inflammation
