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Both are legitimate, mechanistically coherent, and encouraging as far as they go
Its core pathological feature is excessive accumulation of adipose tissue, accompanied by abnormal proliferation, differentiation, and metabolic dysfunction of adipocytes, which in turn induce a series of complications including insulin resistance, nonalcoholic fatty liver disease, and cardiovascular diseases
Nearly 70% of participants lost more than 10% of their body weight, and over 50% lost more than 15%
Crane et al (9)
