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Blood 136 , 183198 (2020)
Any research protocol must be meticulously planned, starting with conservative dosages and making incremental adjustments based on observed data
Through promotion of kynurenine accumulation, Tregs induce indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells, which results in tryptophan depletion and immunosuppression, as kynurenine enhances Treg proliferation and suppresses Teff cells [25, 27]
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