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During AD, an uncoupling between the insulin receptor (IR) and the insulin receptor substrate 1 (IRS1) occurs as a consequence of the downregulation of IR expression and/or the inactivation of IRS proteins leading to the inability of insulin to promote its normal cellular downstream outcomes

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An overview of dietary l-carnitine metabolism in humans, its relationship to both BB and CVD risks, and the impact of preceding dietary pattern (omnivorous versus vegan/vegetarian), as well as chronic l-carnitine supplementation, as revealed by the present studies, are summarized in the scheme shown in Figure 10

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