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Together, these data show that loss of ABCC1 increases the sensitivity of leukemia cells to AZD-4320 treatment in vivo and in vitro
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For instance, NAD + levels and mitochondrial function have been shown to decline in sarcopenia muscle in one cohort 249 , while another study did not observe a difference in NAD + levels in sarcopenic muscle, and even NR supplementation had no effect on NAD + levels 262
