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doi: 10.1016/j.chembiol.2013.08.010
Phthalimide conjugation as a strategy for in vivo target protein degradation
Following stress stimuli, the activation of NRF2 promotes a broad spectrum of downstream target genes involved in various cellular processes such as iron catabolism ( FTH1 , FTL ), metabolism ( G6PD , TKT ), antioxidant signaling ( TXN , GCLC , GCLM ), and xenobiotic transformation ( NQO1 ) [31]
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