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What Causes Glutathione Depletion

At necropsy on day 21, absolute and relative spleen weights were increased in the dams at 51 and 200 mg/m 3 , but there were no treatment-related effects on gravid uterine weight, liver weight or kidney weight, on pre- or postimplantation loss, including resorptions and dead fetuses, on the sex ratio of live fetuses, on fetal body weights per litter or on the incidence of fetal malformations or variations

In contrast, the methylation and glycosylation of OH groups in flavonoids reduce their prooxidant behavior by catechol-o-methyltransferase (COMT) and other enzymes