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A novel mechanism of hepatocellular carcinoma cell apoptosis induced by lupeol via Brain-derived neurotrophic factor inhibition and glycogen synthase kinase 3 beta reactivation

When a too high concentration of antioxidants (e.g., ascorbate) is used, a switch from antioxidant to prooxidant behavior may occur, especially under certain conditions (e.g., highly oxygenated tissues such as lungs or the presence of redox-active metals such as Cu or Fe)

Front Biosci 8 : d520d550

This patient's hypotension and tachycardia indicate severe hypovolemia, which would robustly stimulate juxtaglomerular cells to increase renin production to support blood pressure