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Conclusions and future directions This study provides evidence that antipsychotic-free patients with schizophrenia have lower GABA-A receptors in the hippocampus, predominantly of the alpha-5 subtype, that is not seen in antipsychotic-treated patients

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Outcome measures include neurological severity scoring, rotarod and beam walk performance, histological assessment of lesion volume, and immunohistochemistry for axonal markers and myelin basic protein

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