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Indeed, intervening in epigenetic processes during CAR-T cells manufacturing with small molecules or metabolites is an emerging strategy to either prevent the loss of CAR expression and exhaustion or to induce a memory phenotype (165)

After 500 AD, the cultivation of hemp became widespread throughout Europe (Clarke and Watson, 2002)

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Moreover, the combination of somatic mutation and loss of heterozygosity (LOH) as a second hit was studied in 25 tumors, finding two somatic hits in 13 tumors (8/18 in MLH1 and 5/7 in MSH2 ) [2]