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Daily oral dosing at 500 g/kg body weight for 19 days reduced body-weight gain by more than 50% relative to controls, and the adipose tissue of treated animals showed increased lipolytic activity

One of the commonly reported microbiome differences between obese/HFD-fed animals and lean controls is an increased Firmicutes : Bacteroidetes ratio 43,44

When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair