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We next tested DZnep on the zebrafish embryonic PAC2 cell line expressing a luminescent reporter of the Per1b gene, a non-mammalian cell type commonly used for circadian studies, and revealed, as observed in mammalian cells, a clear effect of the drug on the circadian period (Fig

Moreover, there was a statistically significant difference in the percentage of IL-6 variation between the two groups (8.4% 11.5 vs

Food and Drug Administration (FDA) has approved the supplemental New Drug Application for pitolisant (Wakix) tablets to treat excessive daytime sleepiness (EDS) in pediatric patients 6 years of age and older with narcolepsy